Click-functionalized compact quantum dots protected by multidentate-imidazole ligands: conjugation-ready nanotags for living-virus labeling and imaging

Pengfei Zhang; Shuhui Liu; Duyang Gao; Dehong Hu; Ping Gong; Zonghai Sheng; Jizhe Deng; Yifan Ma; Lintao Cai

doi:10.1021/ja302367s

Click-functionalized compact quantum dots protected by multidentate-imidazole ligands: conjugation-ready nanotags for living-virus labeling and imaging

J Am Chem Soc. 2012 May 23;134(20):8388-91. doi: 10.1021/ja302367s. Epub 2012 May 11.

Authors

Pengfei Zhang¹, Shuhui Liu, Duyang Gao, Dehong Hu, Ping Gong, Zonghai Sheng, Jizhe Deng, Yifan Ma, Lintao Cai

Affiliation

¹ CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Chinese Academy of Sciences, Shenzhen, PR China.

PMID: 22568447
DOI: 10.1021/ja302367s

Abstract

We synthesized a new class of mutifunctional multidentate-imidazole polymer ligands by one-step reaction to produce conjugation-ready QDs with great stability and compact size. Furthermore, combined with strain-promoted click chemistry, we developed a general strategy for efficient labeling of living-viruses with QD probes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line
Cell Proliferation
Click Chemistry
Fluorescent Dyes / chemistry*
Humans
Hydrodynamics
Imidazoles / chemistry*
Ligands
Microscopy, Fluorescence* / methods
Models, Molecular
Quantum Dots*
Virus Internalization
Virus Physiological Phenomena
Viruses / isolation & purification*
Viruses / ultrastructure

Substances

Fluorescent Dyes
Imidazoles
Ligands