Abstract
Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the synthesis of polyhydroquinoline derivatives. This is an environmentally friendly and efficient procedure providing good to excellent yields.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates / chemistry
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Acetoacetates / chemistry
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Acridines / chemical synthesis*
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Aldehydes / chemistry*
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Aniline Compounds / chemistry*
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Catalysis
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Cyclohexanones / chemistry*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Quinolines / chemical synthesis*
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Water / chemistry*
Substances
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Acetates
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Acetoacetates
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Acridines
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Aldehydes
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Aniline Compounds
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Cyclohexanones
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Quinolines
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Water
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ethyl acetoacetate
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ammonium acetate
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methylaniline