The cytochrome P-450 2C9/2C19 but not the ABCB1 genetic polymorphism may be associated with the liver cytochrome 3A4 induction by phenytoin

J Clin Psychopharmacol. 2012 Jun;32(3):429-31. doi: 10.1097/JCP.0b013e3182549c0c.
No abstract available

Publication types

  • Letter

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
  • Adult
  • Alleles
  • Anticonvulsants / blood
  • Anticonvulsants / pharmacokinetics
  • Anticonvulsants / pharmacology*
  • Aryl Hydrocarbon Hydroxylases / genetics*
  • Aryl Hydrocarbon Hydroxylases / metabolism
  • Breath Tests
  • Cytochrome P-450 CYP2C19
  • Cytochrome P-450 CYP2C9
  • Cytochrome P-450 CYP3A / biosynthesis*
  • Enzyme Induction / drug effects
  • Erythromycin / analogs & derivatives
  • Erythromycin / analysis
  • Erythromycin / pharmacokinetics
  • France
  • Gene Frequency
  • Humans
  • Liver / drug effects*
  • Liver / enzymology
  • Male
  • Middle Aged
  • Phenytoin / blood
  • Phenytoin / pharmacokinetics
  • Phenytoin / pharmacology*
  • Polymorphism, Genetic*
  • Radioactive Tracers
  • Young Adult

Substances

  • (N-methyl) erythromycin
  • ABCB1 protein, human
  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Anticonvulsants
  • Radioactive Tracers
  • Phenytoin
  • Erythromycin
  • CYP2C9 protein, human
  • Cytochrome P-450 CYP2C9
  • Aryl Hydrocarbon Hydroxylases
  • CYP2C19 protein, human
  • Cytochrome P-450 CYP2C19
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human