The goal of this research is to use the information contained in the mechanisms occurring during the laser tattoo removal process. We simultaneously employed a laser-beam deflection probe (LBDP) to measure the shock wave and a camera to detect the plasma radiation, both originating from a high-intensity laser-pulse interaction with a tattoo. The experiments were performed in vitro (skin phantoms), ex vivo (marking tattoos on pig skin), and in vivo (professional and amateur decorative tattoos). The LBDP signal includes the information about the energy released during the interaction and indicates textural changes in the skin, which are specific for different skin and tattoo conditions. Using both sensors, we evaluated a measurement of threshold for skin damage and studied the effect of multiple pulses. In vivo results show that a prepulse reduces the interaction strength and that a single strong pulse produces better removal results.