Aqueous and alcoholic extracts of Vitis indica were tested for diuretic activity in rats. The parameters studied on individual rats were body weight before and after test period, total urine volume, urine concentration of Na+,Ka+ and Cr. In the present study, alcoholic and aqueous extracts of Vitis indica leaves (200 mg/kg body weight) shows increase in urine volume, cationic and anionic excretion. Fruosemide (100 mg/kg body weight) is used as a standard.