Improved synthesis of a DNA-dependent protein kinase inhibitor IC86621

Girish Chandra; Varughese Alexander; Hyuk Woo Lee; Lak Shin Jeong

doi:10.1007/s12272-012-0407-1

Improved synthesis of a DNA-dependent protein kinase inhibitor IC86621

Arch Pharm Res. 2012 Mar;35(4):639-45. doi: 10.1007/s12272-012-0407-1. Epub 2012 May 3.

Authors

Girish Chandra¹, Varughese Alexander, Hyuk Woo Lee, Lak Shin Jeong

Affiliation

¹ Department of Bioinspired Science and Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Korea.

PMID: 22553056
DOI: 10.1007/s12272-012-0407-1

Abstract

An improved synthesis of DNA-dependent protein kinase inhibitor, IC86621 is described. This developed method provides an easy access to this simple molecule by using amination, acetylation and Fries rearrangement reactions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetophenones / chemical synthesis*
Acetophenones / chemistry
Acetophenones / pharmacology
Amination
Chemistry Techniques, Synthetic / methods
DNA-Activated Protein Kinase / antagonists & inhibitors*
Drug Design*
Molecular Structure
Morpholines / chemical synthesis*
Morpholines / chemistry
Morpholines / pharmacology
Phenols / chemistry
Protein Kinase Inhibitors / chemical synthesis*
Protein Kinase Inhibitors / chemistry
Protein Kinase Inhibitors / pharmacology

Substances

1-(2-hydroxy-4-morpholin-4-ylphenyl)ethanone
Acetophenones
Morpholines
Phenols
Protein Kinase Inhibitors
DNA-Activated Protein Kinase
3-bromophenol