Cushing disease with pregnancy

Gynecol Endocrinol. 2012 Jul;28(7):533-5. doi: 10.3109/09513590.2011.632789. Epub 2012 May 2.

Abstract

Pregnancy occurs rarely in patients with Cushing syndrome (CS) due to hypercortisolism. So far, about 150 cases of CS in pregnancy have been reported in the literature. We describe a 22-year-old female who presented in pregnancy with clinical features of CS. She delivered at 34 weeks of gestation and baby had transient adrenal insufficiency in the neonatal period. Mother underwent transsphenoidal surgery 1 year postpartum and on follow up she is under remission. Neonatal hypoadrenalism should be anticipated in maternal CS.

Publication types

  • Case Reports

MeSH terms

  • ACTH-Secreting Pituitary Adenoma / physiopathology
  • ACTH-Secreting Pituitary Adenoma / surgery
  • Adenoma / physiopathology
  • Adenoma / surgery
  • Adrenal Insufficiency / congenital
  • Adrenal Insufficiency / drug therapy
  • Adrenal Insufficiency / etiology
  • Adult
  • Cushing Syndrome / diagnosis*
  • Cushing Syndrome / etiology
  • Cushing Syndrome / physiopathology*
  • Cushing Syndrome / therapy
  • Diagnosis, Differential
  • Female
  • Humans
  • Hydrocortisone / therapeutic use
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / drug therapy
  • Infant, Premature, Diseases / etiology
  • Pregnancy
  • Pregnancy Complications / diagnosis*
  • Pregnancy Complications / etiology
  • Pregnancy Complications / physiopathology*
  • Pregnancy Complications / therapy
  • Premature Birth / etiology
  • Respiratory Distress Syndrome, Newborn / etiology
  • Respiratory Distress Syndrome, Newborn / therapy
  • Treatment Outcome
  • Young Adult

Substances

  • Hydrocortisone