Identification of a key prenyltransferase involved in biosynthesis of the most abundant fungal meroterpenoids derived from 3,5-dimethylorsellinic acid

Takayuki Itoh; Kinya Tokunaga; Edayileveettil K Radhakrishnan; Isao Fujii; Ikuro Abe; Yutaka Ebizuka; Tetsuo Kushiro

doi:10.1002/cbic.201200124

Identification of a key prenyltransferase involved in biosynthesis of the most abundant fungal meroterpenoids derived from 3,5-dimethylorsellinic acid

Chembiochem. 2012 May 29;13(8):1132-5. doi: 10.1002/cbic.201200124. Epub 2012 Apr 30.

Authors

Takayuki Itoh¹, Kinya Tokunaga, Edayileveettil K Radhakrishnan, Isao Fujii, Ikuro Abe, Yutaka Ebizuka, Tetsuo Kushiro

Affiliation

¹ Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

PMID: 22549923
DOI: 10.1002/cbic.201200124

Abstract

Destroying aromaticity: A novel prenyltransferase (Trt2) involved in fungal meroterpenoid biosynthesis was shown to catalyze an unusual aromatic addition reaction onto a fully substituted aromatic ring. The prenylated product serves as a key intermediate in the biosynthesis of the most abundant series of meroterpenoids in fungi.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dimethylallyltranstransferase / chemistry
Dimethylallyltranstransferase / metabolism*
Fungal Proteins / chemistry
Fungal Proteins / metabolism*
Fungi / enzymology*
Fungi / metabolism
Resorcinols / metabolism*
Structure-Activity Relationship
Terpenes / metabolism*

Substances

Fungal Proteins
Resorcinols
Terpenes
orsellinic acid
Dimethylallyltranstransferase