Abstract
A TiCl(4)-promoted domino semipinacol-Schmidt reaction of oxaspiropentane-azide provides an easy access to bridged azatricyclic ring systems, which possess the azaquaternary center, present in the immunosupressant FR901483 and platelet aggregation inhibitor daphlongeranine B.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Aza Compounds / chemistry*
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Azides / chemistry
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Crystallography, X-Ray
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Cyclohexenes / chemistry*
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Molecular Conformation
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Organophosphorus Compounds / chemistry
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Platelet Aggregation Inhibitors / chemistry
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Stereoisomerism
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Titanium / chemistry*
Substances
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Alkaloids
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Aza Compounds
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Azides
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Cyclohexenes
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FR 901483
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Organophosphorus Compounds
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Platelet Aggregation Inhibitors
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daphlongeranine B
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semipinacol
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titanium tetrachloride
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Titanium