Contactless conductivity biosensor in microchip containing folic acid as bioreceptor

Lab Chip. 2012 May 8;12(11):1963-6. doi: 10.1039/c2lc40157f. Epub 2012 May 2.

Abstract

We report a glass/PDMS-based microfluidic biosensor that integrates contactless conductivity transduction and folic acid, a target for tumor biomarker, as a bioreceptor. The device presents relevant advantages such as direct determination--dismiss the use of redox mediators as in faradaic electrochemical techniques--and the absence of the known drawbacks related to the electrode-solution interface. Characterizations of the functionalization processes and chemical sensor are described in this communication.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / analysis
  • Biosensing Techniques*
  • Dimethylpolysiloxanes / chemistry
  • Electric Conductivity
  • Electrodes
  • Folic Acid / chemistry*
  • Glass
  • Humans
  • Microfluidic Analytical Techniques
  • Neoplasms / diagnosis
  • Oxidation-Reduction

Substances

  • Biomarkers, Tumor
  • Dimethylpolysiloxanes
  • baysilon
  • Folic Acid