An aptazyme-based molecular device that converts a small-molecule input into an RNA output

Shotaro Ayukawa; Yoko Sakai; Daisuke Kiga

doi:10.1039/c2cc31886e

An aptazyme-based molecular device that converts a small-molecule input into an RNA output

Chem Commun (Camb). 2012 Aug 7;48(61):7556-8. doi: 10.1039/c2cc31886e. Epub 2012 Apr 30.

Authors

Shotaro Ayukawa¹, Yoko Sakai, Daisuke Kiga

Affiliation

¹ Department of Computational Intelligence and Systems Science, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Japan 226-8503.

PMID: 22543508
DOI: 10.1039/c2cc31886e

Abstract

We describe the construction of an aptazyme-based molecular device that converts, through a cascade of reactions, a small-molecule input into output RNA strands. This device is applicable as an interface between a small molecule and a molecular system that accepts only nucleic acid input.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aptamers, Nucleotide / chemistry
Aptamers, Nucleotide / metabolism*
Biosensing Techniques / methods*
DNA, Catalytic / metabolism*
Flavin Mononucleotide / metabolism*
RNA / analysis
RNA / metabolism*
RNA, Catalytic / metabolism*

Substances

Aptamers, Nucleotide
DNA, Catalytic
RNA, Catalytic
RNA
Flavin Mononucleotide