Infections caused by herpes viruses other than cytomegalovirus in solid organ transplant recipients

Abstract

Despite great advances in solid organ transplantation (SOT) in recent decades, infection remains a major cause of morbidity and mortality among SOT recipients. Members of the herpesvirus family are the most common viral pathogens causing disease in this patient population. Herpes viruses are large enveloped DNA viruses that commonly reactivate during periods of severe immunosuppression. Currently, infections caused by herpes viruses continue to complicate clinical management of transplant patients. Although cytomegalovirus (CMV) is the most important virus of this family and is the subject of active research, herpes simplex virus (HSV) and varicella-zoster virus (VZV) can also lead to severe disease. Epstein-Barr virus (EBV) associated with post-transplant lymphoproliferative disease is increasingly recognized as a major complication of SOT. There is less information available on the role and impact of other viruses of the herpesvirus family, such as the human herpes virus 6 (HHV-6), human herpes virus 7 (HHV-7) and human herpes virus 8 (HHV-8). This review summarizes current knowledge regarding epidemiology, clinical manifestations, diagnosis, treatment and prevention of infections caused by herpes viruses other than CMV in SOT recipients.