Abstract
We report a general synthetic approach to the preparation of highly functionalized amine and amino acid derivatives of [60]fullerene starting from readily available chlorofullerene C(60)Cl(6). The synthesized water-soluble amino acid derivative of C(60) demonstrated pronounced antiviral activity, while the cationic amine-based compound showed strong antibacterial action in vitro.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amines / chemistry*
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Amino Acids / chemistry*
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Animals
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology
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Bacillus subtilis / drug effects
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Bacillus subtilis / growth & development
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Cations
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Chlorocebus aethiops
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Crystallography, X-Ray
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Cytomegalovirus / drug effects
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Cytomegalovirus / physiology
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Escherichia coli / drug effects
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Escherichia coli / growth & development
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Fibroblasts / drug effects
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Fibroblasts / virology
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Fullerenes / chemistry*
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Humans
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Injections, Intraperitoneal
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Lethal Dose 50
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Magnetic Resonance Spectroscopy
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Mice
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Simplexvirus / drug effects
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Simplexvirus / physiology
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Vero Cells / drug effects
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Vero Cells / virology
Substances
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Amines
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Amino Acids
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Anti-Bacterial Agents
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Antiviral Agents
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Cations
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Fullerenes
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fullerene C60