Abstract
The H275Y oseltamivir resistance mutation confers high-level resistance to oseltamivir in isolates of human A(H1N1) influenza. We report the recovery and identification of an influenza B virus with the H273Y neuraminidase point mutation directly from a human patient. The H273Y influenza B isolate is resistant to oseltamivir and peramivir but sensitive to zanamivir.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acids, Carbocyclic
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Adult
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Antiviral Agents / pharmacology
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Catalytic Domain
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Cyclopentanes / pharmacology
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Drug Resistance, Viral
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Guanidines / pharmacology
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Humans
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Influenza B virus / drug effects
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Influenza B virus / genetics*
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Influenza B virus / isolation & purification*
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Influenza, Human / virology*
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Male
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Molecular Sequence Data
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Mutation, Missense
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Neuraminidase / genetics*
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Oseltamivir / pharmacology
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Point Mutation*
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RNA, Viral / genetics
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Sequence Analysis, DNA
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Zanamivir / pharmacology
Substances
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Acids, Carbocyclic
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Antiviral Agents
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Cyclopentanes
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Guanidines
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RNA, Viral
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Oseltamivir
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Neuraminidase
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Zanamivir
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peramivir