A fluorescence turn-on H2O2 probe exhibits lysosome-localized fluorescence signals

Chem Commun (Camb). 2012 Jun 4;48(44):5449-51. doi: 10.1039/c2cc31632c. Epub 2012 Apr 26.

Abstract

A new fluorescence turn-on probe that responds exclusively to H(2)O(2) exhibits subcellular localized fluorescence staining of lysosomes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Coordination Complexes / chemistry*
  • Fluoresceins / chemistry*
  • Fluorescent Dyes / chemistry*
  • HeLa Cells
  • Humans
  • Hydrogen Peroxide / chemistry*
  • Iron / chemistry
  • Lysosomes / chemistry*
  • Lysosomes / metabolism
  • Microscopy, Fluorescence
  • Molecular Imaging / methods
  • Molecular Structure
  • Oxidation-Reduction
  • Reactive Oxygen Species / chemistry
  • Sensitivity and Specificity
  • Spectrometry, Fluorescence

Substances

  • Coordination Complexes
  • Fluoresceins
  • Fluorescent Dyes
  • Reactive Oxygen Species
  • Hydrogen Peroxide
  • Iron
  • zinpyr-1