Low molecular mass dermatan sulfate modulates endothelial cells proliferation and migration

Rita Yanina Rasente; Paula Egitto; Graciela Cristina Calabrese

doi:10.1016/j.carres.2012.03.036

Low molecular mass dermatan sulfate modulates endothelial cells proliferation and migration

Carbohydr Res. 2012 Jul 15:356:233-7. doi: 10.1016/j.carres.2012.03.036. Epub 2012 Apr 5.

Authors

Rita Yanina Rasente¹, Paula Egitto, Graciela Cristina Calabrese

Affiliation

¹ Biological Science Department, School of Pharmacy and Biochemistry, University of Buenos Aires, Junín 956, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina.

PMID: 22533918
DOI: 10.1016/j.carres.2012.03.036

Abstract

Low molecular mass dermatan sulfate, obtained by depolymerization, induced the entrance in S phase of mitosis, enhanced the activity of matrix metalloproteinase-2, and could modulate cell migration of endothelial cells, through mechanisms independent of TNF-α autocrine regulation. LMMDS located at the injured sites could influence early stages of angiogenesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Movement / drug effects
Cell Proliferation / drug effects
Cells, Cultured
Dermatan Sulfate / pharmacology*
Endothelial Cells / cytology
Endothelial Cells / drug effects*
Endothelial Cells / metabolism
Matrix Metalloproteinase 2 / genetics
Matrix Metalloproteinase 2 / metabolism*
Mice
Molecular Weight
Myocardium / cytology
S Phase / drug effects
Tumor Necrosis Factor-alpha / biosynthesis
Tumor Necrosis Factor-alpha / metabolism
Up-Regulation

Substances

Tumor Necrosis Factor-alpha
Dermatan Sulfate
Matrix Metalloproteinase 2