The role of lipophilicity in transmembrane anion transport

Chem Commun (Camb). 2012 May 28;48(43):5274-6. doi: 10.1039/c2cc31825c. Epub 2012 Apr 24.

Abstract

The transmembrane anion transport activity of a series of synthetic molecules inspired by the structure of tambjamine alkaloids can be tuned by varying the lipophilicity of the receptor, with carriers within a certain log P range performing best.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anions / chemistry
  • Anions / metabolism*
  • Biological Products / chemistry
  • Biological Products / metabolism
  • Hydrophobic and Hydrophilic Interactions
  • Ion Transport
  • Lipid Bilayers / chemistry
  • Lipid Bilayers / metabolism*
  • Phosphatidylcholines / chemistry

Substances

  • Anions
  • Biological Products
  • Lipid Bilayers
  • Phosphatidylcholines
  • 1-palmitoyl-2-oleoylphosphatidylcholine