Woodsmoke marker levoglucosan: kinetics in a self-experiment

Int J Occup Med Environ Health. 2012 Jun;25(2):122-5. doi: 10.2478/S13382-012-0023-9. Epub 2012 Apr 19.

Abstract

Objectives: Concerns on climate change are leading to the renaissance of wood burning and particulate exposures. Levoglucosan is used as a marker of woodsmoke in air and urine.

Objectives: Contribution of data on urinary excretion of levoglucosan, to improve biomonitoring and source apportionment of woodsmoke.

Materials and methods: 1, 3, 5, and 7 hours after 5 mg of levoglucosan had been administered orally, urinary excretion was measured by HPLC and mass spectrometry.

Results: After oral intake, urine concentrations increased rapidly, reached highest values after 3 hours, and after 7 hours approximately 70% of the administered dose was excreted.

Conclusions: Urinary levoglucosan may be used for biomonitoring of woodsmoke exposure on the same day.

MeSH terms

  • Administration, Oral
  • Air Pollutants / urine*
  • Biomarkers / urine
  • Environmental Exposure / analysis*
  • Environmental Monitoring / methods*
  • Fires
  • Glucose / administration & dosage
  • Glucose / analogs & derivatives*
  • Glucose / analysis
  • Humans
  • Male
  • Middle Aged
  • Smoke*
  • Wood / chemistry

Substances

  • Air Pollutants
  • Biomarkers
  • Smoke
  • 1,6-anhydro-beta-glucopyranose
  • Glucose