The ability of female sex steroids to regulate tissue function has long been appreciated; however, their role in the regulation of striated muscle function has received considerably less attention. The purpose of this symposium review was to document recent evidence indicating the role female sex steroids have in defining the functional characteristics of striated muscle. The presentations provide substantial evidence indicating that estrogens are critical to the physiological and metabolic regulations of striated muscle; thus, when considering women's health issues, striated muscle must included as an important target tissue along with other classically thought of estrogen-sensitive tissues.