Abstract
Many different glycoconjugates, including saponins (e.g., hellebrin) and anthracyclines (e.g., doxorubicin), are known to display cytotoxic activities. In recent work, we have developed synthetic protocols for the synthesis of various glycoconjugates, focusing on glycosylation methods for different classes of biomolecules. Simultaneously a number of saponins and anthracyclines have been generated. In this note, the cytotoxic activities of these synthesized compounds are briefly addressed.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anthracyclines / chemical synthesis
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Anthracyclines / pharmacology*
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Antibiotics, Antineoplastic / chemical synthesis
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Antibiotics, Antineoplastic / pharmacology*
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Cell Line, Tumor
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Cell Proliferation
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Cell Survival
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Doxorubicin / chemical synthesis
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Doxorubicin / pharmacology*
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Female
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Glycoconjugates / chemical synthesis
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Glycoconjugates / pharmacology*
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Humans
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Inhibitory Concentration 50
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Saponins / chemical synthesis
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Saponins / pharmacology*
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Steroids / chemical synthesis
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Steroids / pharmacology*
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Structure-Activity Relationship
Substances
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Anthracyclines
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Antibiotics, Antineoplastic
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Glycoconjugates
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Saponins
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Steroids
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Doxorubicin