Abstract
Voriconazole is used in antifungal prophylaxis. We performed a retrospective review of immunocompromised children receiving prophylaxis with voriconazole during major hospital renovation, who developed phototoxic skin reactions. The overall incidence of phototoxic skin reactions was 33%. A voriconazole dose of ≥6 mg/kg of body weight per dose twice daily was associated with a significantly greater risk to develop phototoxic skin reactions compared with lower doses.
MeSH terms
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Chemoprevention / adverse effects*
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Chemoprevention / methods*
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Child
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Child, Preschool
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Dermatitis, Phototoxic / epidemiology*
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Female
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Humans
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Immunocompromised Host
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Incidence
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Infant
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Male
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Mycoses / prevention & control
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Neoplasms / complications
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Neoplasms / drug therapy
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Pyrimidines / administration & dosage*
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Pyrimidines / adverse effects*
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Retrospective Studies
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Risk Assessment
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Triazoles / administration & dosage*
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Triazoles / adverse effects*
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Voriconazole
Substances
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Pyrimidines
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Triazoles
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Voriconazole