Nasopharyngeal lactate dehydrogenase concentrations predict bronchiolitis severity in a prospective multicenter emergency department study

Pediatr Infect Dis J. 2012 Jul;31(7):767-9. doi: 10.1097/INF.0b013e3182565eae.

Abstract

We reexamined the finding of an inverse relationship between values of nasopharyngeal lactate dehydrogenase, a marker of the innate immune response, and bronchiolitis severity. In a prospective, multicenter study of 258 children, we found in a multivariable model that higher nasopharyngeal lactate dehydrogenase values in young children with bronchiolitis were independently associated with a decreased risk of hospitalization.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bronchiolitis / diagnosis*
  • Bronchiolitis / pathology*
  • Cohort Studies
  • Emergency Medicine / methods
  • Female
  • Hospitalization / statistics & numerical data
  • Humans
  • Infant
  • Infant, Newborn
  • L-Lactate Dehydrogenase / analysis*
  • Male
  • Nasopharynx / enzymology*
  • Prognosis
  • Prospective Studies
  • Severity of Illness Index
  • Statistics as Topic

Substances

  • L-Lactate Dehydrogenase