Abstract
The development of novel peptide and peptidomimetic ligands for the CXC chemokine receptor 4 (CXCR4) as therapeutic agents for HIV-1 infection, cancer, and immune system diseases has grown over the last decade. In this perspective article, the design of CXCR4 agonists and antagonists from endogenous stromal cell-derived factor-1 (SDF-1)/CXCL12 and horseshoe crab-derived antimicrobial peptides and their therapeutic and diagnostic applications are described.
MeSH terms
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Amino Acid Sequence
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Animals
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Chemokine CXCL12 / chemistry
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Ligands
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Molecular Imaging
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Molecular Sequence Data
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Peptides / chemistry
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Peptides / metabolism*
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Peptides / pharmacology
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Peptidomimetics / chemistry
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Peptidomimetics / metabolism*
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Peptidomimetics / pharmacology
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Receptors, CXCR4 / antagonists & inhibitors
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Receptors, CXCR4 / chemistry
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Receptors, CXCR4 / metabolism*
Substances
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Chemokine CXCL12
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Ligands
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Peptides
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Peptidomimetics
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Receptors, CXCR4