Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4)

Org Biomol Chem. 2012 Aug 14;10(30):5720-31. doi: 10.1039/c2ob25107h. Epub 2012 Apr 19.

Abstract

The development of novel peptide and peptidomimetic ligands for the CXC chemokine receptor 4 (CXCR4) as therapeutic agents for HIV-1 infection, cancer, and immune system diseases has grown over the last decade. In this perspective article, the design of CXCR4 agonists and antagonists from endogenous stromal cell-derived factor-1 (SDF-1)/CXCL12 and horseshoe crab-derived antimicrobial peptides and their therapeutic and diagnostic applications are described.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chemokine CXCL12 / chemistry
  • Ligands
  • Molecular Imaging
  • Molecular Sequence Data
  • Peptides / chemistry
  • Peptides / metabolism*
  • Peptides / pharmacology
  • Peptidomimetics / chemistry
  • Peptidomimetics / metabolism*
  • Peptidomimetics / pharmacology
  • Receptors, CXCR4 / antagonists & inhibitors
  • Receptors, CXCR4 / chemistry
  • Receptors, CXCR4 / metabolism*

Substances

  • Chemokine CXCL12
  • Ligands
  • Peptides
  • Peptidomimetics
  • Receptors, CXCR4