A new asymmetric diamide from the seed cake of Jatropha curcas L

Licheng Yao; Changri Han; Guangying Chen; Xiaoping Song; Yonghui Chang; Wenxia Zang

doi:10.1016/j.fitote.2012.04.001

A new asymmetric diamide from the seed cake of Jatropha curcas L

Fitoterapia. 2012 Dec;83(8):1318-21. doi: 10.1016/j.fitote.2012.04.001. Epub 2012 Apr 11.

Authors

Licheng Yao¹, Changri Han, Guangying Chen, Xiaoping Song, Yonghui Chang, Wenxia Zang

Affiliation

¹ Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, PR China.

PMID: 22516541
DOI: 10.1016/j.fitote.2012.04.001

Abstract

A new asymmetric diamide (E)-N-(3-acetamidopropyl)-cinnamamide named curcamide (1) has been isolated from the ethanol extract of the seed cake of Jatropha curcas L. along with 7 known compounds identified as isoamericanin (2), isoprincepin (3), caffeoylaldehyde (4), isoferulaldehyde (5), glycerol monooleate (6), syringaldehyde (7), and β-ethyl-d-glucopyranoside (8). The synthesis and antibacterial activity of the new compound have been also studied.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amides / chemistry*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / pharmacology
Bacteria / drug effects
Cell Line, Tumor
Cinnamates / chemistry*
Diamide / chemistry*
Humans
Jatropha / chemistry*
Microbial Sensitivity Tests
Seeds

Substances

Amides
Anti-Bacterial Agents
Antineoplastic Agents, Phytogenic
Cinnamates
curcamide
Diamide