Hijacking T cell differentiation: new insights in TLX function in T-ALL

Bryan King; Panagiotis Ntziachristos; Iannis Aifantis

doi:10.1016/j.ccr.2012.03.026

Hijacking T cell differentiation: new insights in TLX function in T-ALL

Cancer Cell. 2012 Apr 17;21(4):453-5. doi: 10.1016/j.ccr.2012.03.026.

Authors

Bryan King¹, Panagiotis Ntziachristos, Iannis Aifantis

Affiliation

¹ Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, NY 10016, USA.

Abstract

TLX1 and TLX3 are two closely-related homeobox transcriptional repressors frequently misexpressed and translocated in T cell acute lymphoblastic leukemia (T-ALL). In this issue of Cancer Cell, Dadi et al. provide new insights into how these factors are recruited by ETS-1 to the TCRα enhancer and actively repress differentiation.

Publication types

Comment

Abstract

Publication types

Grants and funding