Abstract
A massive extravasation of pegylated-liposomal doxorubicin (Doxil) accidentally occurred, affecting the right forearm of a 54-year-old woman with metastatic ovarian cancer who was receiving an intravenous infusion of the drug. In accordance with the institutional guidelines for vesicant drugs, a corticosteroid preparation was immediately injected subcutaneously into the surrounding tissues. Clobetasol propionate and an ice pack were then topically applied to the affected region. There were no serious complications at the extravasation site, such as tissue necrosis or severe pain, and only a transient erythema of the skin and desquamation remained after 2 months.
MeSH terms
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Administration, Cutaneous
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Adrenal Cortex Hormones / administration & dosage*
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Antibiotics, Antineoplastic / administration & dosage
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Antibiotics, Antineoplastic / adverse effects*
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Clobetasol / administration & dosage
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Doxorubicin / administration & dosage
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Doxorubicin / adverse effects
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Doxorubicin / analogs & derivatives*
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Edema / drug therapy
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Edema / etiology
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Erythema / drug therapy
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Erythema / etiology
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Extravasation of Diagnostic and Therapeutic Materials / drug therapy*
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Extravasation of Diagnostic and Therapeutic Materials / etiology
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Female
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Forearm / blood supply*
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Glucocorticoids / administration & dosage
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Humans
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Hypothermia, Induced
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Infusions, Intravenous
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Injections, Subcutaneous
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Middle Aged
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Ovarian Neoplasms / drug therapy*
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Ovarian Neoplasms / pathology
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Polyethylene Glycols / administration & dosage
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Polyethylene Glycols / adverse effects*
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Treatment Outcome
Substances
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Adrenal Cortex Hormones
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Antibiotics, Antineoplastic
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Glucocorticoids
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liposomal doxorubicin
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Polyethylene Glycols
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Doxorubicin
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Clobetasol