Dogs of nomadic pastoralists in northern Kenya are reservoirs of plasmid-mediated cephalosporin- and quinolone-resistant Escherichia coli, including pandemic clone B2-O25-ST131

Antimicrob Agents Chemother. 2012 Jul;56(7):4013-7. doi: 10.1128/AAC.05859-11. Epub 2012 Apr 16.

Abstract

Resistance in Escherichia coli isolates colonizing gastrointestinal tracts of dogs, cats, and their owners in Northern Kenya was investigated with an emphasis on extended-spectrum beta-lactamases (ESBLs). Totals of 47 (22%, n = 216), 2 (4%, n = 50), and 4 (17%, n = 23) CTX-M-15-producing E. coli isolates were obtained from dogs, cats, and humans, respectively. CTX-M-15-producing E. coli isolates with identical PFGE profiles were detected in animals and humans living in the same area.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cats
  • Cephalosporins / pharmacology*
  • Dogs
  • Drug Resistance, Multiple, Bacterial / genetics
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics*
  • Humans
  • Kenya
  • Plasmids / genetics*
  • Quinolones / pharmacology*
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism

Substances

  • Cephalosporins
  • Quinolones
  • beta-Lactamases