Treatment of γ-aminobutyric acid B receptor-antibody autoimmune encephalitis with oral corticosteroids

Arch Neurol. 2012 Aug;69(8):1061-3. doi: 10.1001/archneurol.2012.197.

Abstract

Background: Autoimmune encephalitis is increasingly identified as a cause of nonviral, idiopathic encephalitis. Present treatment algorithms recommend costly immune-modulating treatments and do not identify a role for oral corticosteroids.

Objective: To present a patient with γ-aminobutyric acid(B) receptor-antibody encephalitis before and after treatment with oral corticosteroids.

Design: Case report.

Setting: The inpatient course as well as outpatient follow-up is discussed.

Patient: A 43-year-old man with initial presentation of seizures and altered mental status.

Intervention: Our patient was treated with an extended course of oral corticosteroids as an outpatient.

Results: After treatment with oral corticosteroids, our patient had steady clinical improvement, achieved seizure freedom, and experienced improved mental status to within normal limits.

Conclusions: This case supports the use of low-cost oral corticosteroids in treating patients with γ-aminobutyric acid(B) receptor-antibody encephalitis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adrenal Cortex Hormones / administration & dosage*
  • Adult
  • Brain Diseases / drug therapy*
  • Brain Diseases / immunology*
  • Encephalitis
  • Follow-Up Studies
  • Hashimoto Disease / drug therapy*
  • Hashimoto Disease / immunology*
  • Humans
  • Male
  • Receptors, GABA-B / immunology*
  • Treatment Outcome

Substances

  • Adrenal Cortex Hormones
  • Receptors, GABA-B

Supplementary concepts

  • Hashimoto's encephalitis