[Study on the chemical constituents from the aerial parts of Medicago sativa and their hypolipidemic activity]

Zhong Yao Cai. 2011 Nov;34(11):1709-11.
[Article in Chinese]

Abstract

Objective: To research the chemical constituents from the aerial parts of Medicago sativa.

Methods: Various column chromatographies were emoployed to isolate and purify the constituents. Their structures were elucidated by spectral analysis (IR, UV, MS, 1H-NMR, 13C-NMR) and chemical evidence.

Results: Two constituents were obtained and identified as soysaponin I (I), azukisaponin V (II).

Conclusion: These two compounds are isolated from the arial parts of Mesicago sativa for the first time. Moreover,the compounds are found to have hypolipidemic activity.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cholesterol / blood
  • Disease Models, Animal
  • Hyperlipidemias / blood
  • Hyperlipidemias / drug therapy
  • Hypolipidemic Agents / isolation & purification
  • Hypolipidemic Agents / pharmacology*
  • Male
  • Medicago sativa / chemistry*
  • Mice
  • Molecular Structure
  • Plant Components, Aerial / chemistry*
  • Saponins / chemistry
  • Saponins / isolation & purification*
  • Saponins / pharmacology*
  • Spectrophotometry, Ultraviolet

Substances

  • Hypolipidemic Agents
  • Saponins
  • azukisaponin V
  • Cholesterol