6''-Thioether tobramycin analogues: towards selective targeting of bacterial membranes

Angew Chem Int Ed Engl. 2012 Jun 4;51(23):5652-6. doi: 10.1002/anie.201200761. Epub 2012 Apr 12.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Cell Wall / drug effects
  • Cell Wall / metabolism*
  • Erythrocytes / drug effects
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Hemolysis
  • Humans
  • Rats
  • Sulfides / chemistry*
  • Tobramycin / analogs & derivatives*
  • Tobramycin / chemical synthesis
  • Tobramycin / pharmacology

Substances

  • Anti-Bacterial Agents
  • Sulfides
  • Tobramycin