CD105 and placental growth factor--potent prognostic factors in childhood acute lymphoblastic leukaemia

Patrycja Sujka-Kordowska; Agnieszka Malinska; Danuta Ostalska-Nowicka; Maciej Zabel; Michal Nowicki

doi:10.1016/j.leukres.2012.03.017

CD105 and placental growth factor--potent prognostic factors in childhood acute lymphoblastic leukaemia

Leuk Res. 2012 Jul;36(7):846-51. doi: 10.1016/j.leukres.2012.03.017. Epub 2012 Apr 10.

Authors

Patrycja Sujka-Kordowska¹, Agnieszka Malinska, Danuta Ostalska-Nowicka, Maciej Zabel, Michal Nowicki

Affiliation

¹ Department of Histology and Embryology, University of Medical Sciences, Poznan, Poland.

PMID: 22498340
DOI: 10.1016/j.leukres.2012.03.017

Abstract

The studies aimed at identifying a prognostic significance of angiogenesis-related factors: CD105 and placental growth factor (PlGF) in a course of acute lymphoblastic leukaemia (ALL). Research protocol was based on detection of RNA and protein expressions in bone marrow blasts using quantitative PCR and immunocytochemical assays respectively. Kaplan-Meier statistics revealed CD105 and PlGF expression as managed separately do not correlate with relapse-free time in ALL patients. On the other hand, an associated analysis of CD105 and PlGF demonstrated a significantly shorter progression-free time in children who were CD105+ and PlGF+ or CD105- and PlGF+ at the moment of ALL diagnosis.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Age of Onset
Antigens, CD / analysis
Antigens, CD / genetics
Antigens, CD / metabolism
Antigens, CD / physiology*
Biomarkers, Tumor* / analysis
Biomarkers, Tumor* / genetics
Biomarkers, Tumor* / metabolism
Case-Control Studies
Child
Endoglin
Gene Expression Regulation, Leukemic
Humans
Immunohistochemistry
Monitoring, Physiologic / methods
Placenta Growth Factor
Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / epidemiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
Pregnancy Proteins / analysis
Pregnancy Proteins / genetics
Pregnancy Proteins / metabolism
Pregnancy Proteins / physiology*
Prognosis
RNA, Messenger / analysis
RNA, Messenger / genetics
RNA, Messenger / metabolism
Receptors, Cell Surface / analysis
Receptors, Cell Surface / genetics
Receptors, Cell Surface / metabolism
Receptors, Cell Surface / physiology*
Risk Factors
Survival Analysis
Time Factors

Substances

Antigens, CD
Biomarkers, Tumor
ENG protein, human
Endoglin
PGF protein, human
Pregnancy Proteins
RNA, Messenger
Receptors, Cell Surface
Placenta Growth Factor