We report nine cases of corneal infiltrates and/or ulceration in patients using disposable extended wear contact lenses. None of the nine patients had worn the lenses more than the recommended 7 days. Cultures were performed on six of the patients; all cultures were negative. One of the six cultured patients had been treated with topical antibiotics prior to culture. All responded promptly to cessation of lens wear and topical antibiotic therapy. Although all of the infiltrates/ulcers were paracentral, none of the patients sustained any permanent visual loss.