Descemet's stripping with automated endothelial keratoplasty (DSAEK) has the advantage of minor surgical injury and fast visual recovery, which has become the optimal surgical choice for endothelial disorders. It has unique complications closely related to surgical maneuver, skill of operation, and proper intervention. The most common complication is graft dislocation. The clinical finding appears corneal edema and whitish. A space is detected between the donor graft and recipient. The risk factors are lens-iris diaphragm defect and vitrectomy eyes. The common situation, rebubbling is a effective method. But viscoelastic maybe needed for abnormal anterior segment structure to reattach the dislocated graft. So DSAEK is a new type of surgery and it is necessary to acknowledge and understand its surgical features and complication.