Synthesis and antimicrobial studies of some novel bis-[1,3,4]thiadiazole and bis-thiazole pendant to thieno[2,3-b]thiophene moiety

Int J Mol Sci. 2012;13(3):3661-3670. doi: 10.3390/ijms13033661. Epub 2012 Mar 19.

Abstract

The synthetic utility of 3,3'-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis (3-oxopropanenitrile) (1) in the synthesis of some novel bis-[1,3,4-thiadiazole] 6a-g and bis-thiazole 10 and 13 derivatives with thieno[2,3-b]thiophene moiety is reported. Antimicrobial evaluation of some selected examples from the synthesized products was carried out and showed promising results.

Keywords: antimicrobial activity; bis-thiadiazoles; bis-thiazoles; hydrazonoyl halides; nucleophilic addition; thieno[2,3-b]thiophene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents* / chemical synthesis
  • Anti-Infective Agents* / chemistry
  • Anti-Infective Agents* / pharmacology
  • Aspergillus fumigatus / drug effects
  • Bacillus subtilis / drug effects
  • Candida albicans / drug effects
  • Clotrimazole / pharmacology
  • Drug Design
  • Escherichia coli / drug effects
  • Geotrichum / drug effects
  • Itraconazole / pharmacology
  • Microbial Sensitivity Tests
  • Penicillin G / pharmacology
  • Pseudomonas aeruginosa / drug effects
  • Staphylococcus aureus / drug effects
  • Streptomycin / pharmacology
  • Thiadiazoles / chemical synthesis*
  • Thiadiazoles / chemistry
  • Thiadiazoles / pharmacology*
  • Thiophenes / chemical synthesis*
  • Thiophenes / chemistry
  • Thiophenes / pharmacology*

Substances

  • Anti-Infective Agents
  • Thiadiazoles
  • Thiophenes
  • 1,3,4-thiadiazole
  • Itraconazole
  • Clotrimazole
  • Penicillin G
  • Streptomycin