Abstract
The synthetic utility of 3,3'-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis (3-oxopropanenitrile) (1) in the synthesis of some novel bis-[1,3,4-thiadiazole] 6a-g and bis-thiazole 10 and 13 derivatives with thieno[2,3-b]thiophene moiety is reported. Antimicrobial evaluation of some selected examples from the synthesized products was carried out and showed promising results.
Keywords:
antimicrobial activity; bis-thiadiazoles; bis-thiazoles; hydrazonoyl halides; nucleophilic addition; thieno[2,3-b]thiophene.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents* / chemical synthesis
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Anti-Infective Agents* / chemistry
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Anti-Infective Agents* / pharmacology
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Aspergillus fumigatus / drug effects
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Bacillus subtilis / drug effects
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Candida albicans / drug effects
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Clotrimazole / pharmacology
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Drug Design
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Escherichia coli / drug effects
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Geotrichum / drug effects
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Itraconazole / pharmacology
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Microbial Sensitivity Tests
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Penicillin G / pharmacology
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Pseudomonas aeruginosa / drug effects
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Staphylococcus aureus / drug effects
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Streptomycin / pharmacology
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Thiadiazoles / chemical synthesis*
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Thiadiazoles / chemistry
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Thiadiazoles / pharmacology*
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Thiophenes / chemical synthesis*
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Thiophenes / chemistry
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Thiophenes / pharmacology*
Substances
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Anti-Infective Agents
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Thiadiazoles
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Thiophenes
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1,3,4-thiadiazole
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Itraconazole
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Clotrimazole
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Penicillin G
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Streptomycin