Abstract
Two new copper(I) hydrazone complexes have been synthesised from bivalent copper precursor [CuCl(2)(PPh(3))(2)] and ferrocene containing bidentate hydrazone ligands HL(1) (1) or HL(2) (2). Based on the elemental analyses and spectroscopic data, the complexes are best formulated as [CuL(1)(PPh(3))(2)] (3) and [CuL(2)(PPh(3))(2)] (4) of the monovalent copper ion. Solid state structures of ligand 2 and its corresponding complex 4 were also determined. The DNA/albumin interactions of all the synthesised compounds were investigated using absorption, emission and synchronous fluorescence studies. Further, antioxidant properties of all the compounds have also been checked against ABTS, O(2)(-) and OH radicals. Additionally, the in vitro cytotoxic activity of compounds 1-4 was assessed using tumour (HeLa, A431) and non-tumour (NIH 3T3) cell lines.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / chemical synthesis
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Antioxidants / chemistry*
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Antioxidants / metabolism
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Antioxidants / pharmacology*
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Binding, Competitive
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Cattle
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Cell Survival / drug effects
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Copper / chemistry*
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Crystallography, X-Ray
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DNA / chemistry
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DNA / metabolism
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Ethidium / chemistry
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Ethidium / metabolism
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Ferrous Compounds / chemistry
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HeLa Cells
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Humans
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Hydrazones / chemistry*
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Metallocenes
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Mice
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Models, Molecular
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NIH 3T3 Cells
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Protein Binding
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Schiff Bases / chemical synthesis
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Schiff Bases / chemistry*
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Schiff Bases / metabolism
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Schiff Bases / pharmacology*
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Serum Albumin, Bovine / chemistry
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Serum Albumin, Bovine / metabolism
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Spectrum Analysis
Substances
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Antioxidants
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Ferrous Compounds
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Hydrazones
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Metallocenes
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Schiff Bases
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Serum Albumin, Bovine
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Copper
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DNA
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Ethidium
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ferrocene