Pyronepolyene C-glucosides with NF-κB inhibitory and anti-influenza A viral (H1N1) activities from the sponge-associated fungus Epicoccum sp. JJY40

Jixing Peng; Jieying Jiao; Jing Li; Wei Wang; Qianqun Gu; Tianjiao Zhu; Dehai Li

doi:10.1016/j.bmcl.2012.03.044

Pyronepolyene C-glucosides with NF-κB inhibitory and anti-influenza A viral (H1N1) activities from the sponge-associated fungus Epicoccum sp. JJY40

Bioorg Med Chem Lett. 2012 May 1;22(9):3188-90. doi: 10.1016/j.bmcl.2012.03.044. Epub 2012 Mar 23.

Authors

Jixing Peng¹, Jieying Jiao, Jing Li, Wei Wang, Qianqun Gu, Tianjiao Zhu, Dehai Li

Affiliation

¹ Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.

PMID: 22487178
DOI: 10.1016/j.bmcl.2012.03.044

Abstract

A new pyronepolyene C-glucoside, named iso-D8646-2-6 (1) together with the known related compound D8646-2-6 (2), was isolated from the sponge-associated fungus Epicoccum sp. JJY40. They showed NF-κB inhibitory and anti-influenza A viral (H1N1) activities.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiviral Agents / isolation & purification
Antiviral Agents / pharmacology*
Ascomycota / chemistry*
Glucosides / isolation & purification
Glucosides / pharmacology*
Humans
Influenza A Virus, H1N1 Subtype / drug effects*
NF-kappa B / antagonists & inhibitors*
Porifera / microbiology*

Substances

Antiviral Agents
Glucosides
NF-kappa B