Comparative study of the expression of ATF-3 and ATF-4 genes in vessels involved into atherosclerosis process and in psoriatic skin

V V Sobolev; N L Starodubtseva; A L Piruzyan; M T Minnibaev; M E Sautin; V P Tumanov; S A Bruskin

doi:10.1007/s10517-011-1423-8

Comparative study of the expression of ATF-3 and ATF-4 genes in vessels involved into atherosclerosis process and in psoriatic skin

Bull Exp Biol Med. 2011 Oct;151(6):713-6. doi: 10.1007/s10517-011-1423-8.

Authors

V V Sobolev¹, N L Starodubtseva, A L Piruzyan, M T Minnibaev, M E Sautin, V P Tumanov, S A Bruskin

Affiliation

¹ N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia. sobolev_vl@mail.ru

PMID: 22485215
DOI: 10.1007/s10517-011-1423-8

Abstract

Expression of ATF-3 and ATF-4 genes was examined quantitatively by real-time PCR and changes in the expression of these genes in atherosclerotic lesions and in psoriatic skin were demonstrated. It was found that concomitant pathologies do not affect the expression of these genes. Opposite changes in the expression of ATF-3 and ATF-4 genes in atherosclerotic and psoriatic samples were revealed and a hypothesis was put forward that this parameter could be a criterion of pathological process in both diseases.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Activating Transcription Factor 3 / genetics*
Activating Transcription Factor 4 / genetics*
Atherosclerosis / genetics*
Humans
In Vitro Techniques
Psoriasis / genetics*
Real-Time Polymerase Chain Reaction
Skin / metabolism*

Substances

ATF3 protein, human
ATF4 protein, human
Activating Transcription Factor 3
Activating Transcription Factor 4