Screening and identification of disaccharides with insulin mimetic activity against L6 cells

Kazuaki Yamasaki; Ryogo Hishiki; Eisuke Kato; Jun Kawabata

doi:10.1271/bbb.110884

Screening and identification of disaccharides with insulin mimetic activity against L6 cells

Biosci Biotechnol Biochem. 2012;76(4):841-2. doi: 10.1271/bbb.110884. Epub 2012 Apr 7.

Authors

Kazuaki Yamasaki¹, Ryogo Hishiki, Eisuke Kato, Jun Kawabata

Affiliation

¹ Laboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita-ku, Sapporo, Japan.

PMID: 22484948
DOI: 10.1271/bbb.110884

Abstract

Insulin mimetics are considered as prospective anti-diabetic agents, and the disaccharide, neohesperidose, has been found to show insulin mimetic activity against L6 cells. We screened several other disaccharides for their insulin mimetic activity and identified three new insulin mimetic disaccharides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biological Transport / drug effects
Biomimetic Materials / chemistry*
Biomimetic Materials / pharmacology
Cell Line
Deoxyglucose / metabolism
Diabetes Mellitus / metabolism
Disaccharides / chemistry*
Disaccharides / pharmacology
Humans
Hypoglycemic Agents / chemistry*
Hypoglycemic Agents / pharmacology
Insulin / pharmacology
Rats

Substances

Disaccharides
Hypoglycemic Agents
Insulin
Deoxyglucose