Synthesis and antitumor-evaluation of 1,3,4-thiadiazole-containing benzisoselenazolone derivatives

Zhenhua Luo; Baoquan Chen; Shuangyan He; Yanping Shi; Yuming Liu; Caiwen Li

doi:10.1016/j.bmcl.2012.03.043

Synthesis and antitumor-evaluation of 1,3,4-thiadiazole-containing benzisoselenazolone derivatives

Bioorg Med Chem Lett. 2012 May 1;22(9):3191-3. doi: 10.1016/j.bmcl.2012.03.043. Epub 2012 Mar 21.

Authors

Zhenhua Luo¹, Baoquan Chen, Shuangyan He, Yanping Shi, Yuming Liu, Caiwen Li

Affiliation

¹ Department of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China.

PMID: 22483583
DOI: 10.1016/j.bmcl.2012.03.043

Abstract

A series of novel 1,3,4-thiadiazole-containing benzisoselenazolone derivatives were prepared by the condensation of 2-chloroselenobenzoyl chloride and 2-amino-5-substituted-1,3,4-thiadiazole. Their in vitro antiproliferative activities were evaluated in SSMC-7721, MCF-7 and A-549 cells. The results suggest that, in different tumor cells, some compounds have good antiproliferative activity, certain selectivity and potential value of further research.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / pharmacology
Azoles / chemical synthesis*
Azoles / pharmacology
Cell Line, Tumor
Drug Screening Assays, Antitumor*
Humans
Thiadiazoles / chemical synthesis*
Thiadiazoles / pharmacology

Substances

Antineoplastic Agents
Azoles
Thiadiazoles
1,3,4-thiadiazole