What's behind the failure of emerging antibiotics in the critically ill? Understanding the impact of altered pharmacokinetics and augmented renal clearance

MeSH terms

• Anti-Bacterial Agents / administration & dosage
• Anti-Bacterial Agents / blood
• Anti-Bacterial Agents / pharmacokinetics*
• Anti-Bacterial Agents / therapeutic use
• Carbapenems / administration & dosage
• Carbapenems / blood
• Carbapenems / pharmacokinetics*
• Carbapenems / therapeutic use
• Cephalosporins / administration & dosage
• Cephalosporins / blood
• Cephalosporins / pharmacokinetics
• Cephalosporins / therapeutic use
• Critical Illness / therapy*
• Cross Infection / drug therapy
• Cross Infection / microbiology
• Doripenem
• Humans
• Kidney / physiology*
• Metabolic Clearance Rate
• Pneumonia / drug therapy
• Pneumonia / microbiology
• Pneumonia, Ventilator-Associated / drug therapy
• Pneumonia, Ventilator-Associated / mortality
• Randomized Controlled Trials as Topic