A novel antioxidant isobenzofuranone derivative from fungus Cephalosporium sp.AL031

Molecules. 2012 Apr 5;17(4):4219-24. doi: 10.3390/molecules17044219.

Abstract

Bioassay-guided fractionation of metabolites from the fungus Cephalosporium sp.AL031 isolated from Sinarundinaria nitida led to the discovery of a new isobenzofuranone derivative, 4,6-dihydroxy-5-methoxy-7-methylphthalide (1), together with three known compounds: 4,5,6-trihydroxy-7-methyl-1,3-dihydroisobenzofuran (2), 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran (3) and 4,5,6-trihydroxy-7-methylphthalide (4). The structure of the new compound 1 was determined based on MS, 1D and 2D NMR spectral data. Compounds 1-4 showed potent antioxidant activity with EC₅₀ values of 10, 7, 22 and 5 μM by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acremonium / chemistry*
  • Antioxidants / analysis
  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Benzofurans / analysis
  • Benzofurans / chemistry
  • Benzofurans / pharmacology*
  • Nuclear Magnetic Resonance, Biomolecular

Substances

  • 4,6-dihydroxy-5-methoxy-7-methylphthalide
  • Antioxidants
  • Benzofurans