Micelles based on gold-glycopolymer complexes as new chemotherapy drug delivery agents

Samuel Pearson; Wei Scarano; Martina H Stenzel

doi:10.1039/c2cc30510k

Micelles based on gold-glycopolymer complexes as new chemotherapy drug delivery agents

Chem Commun (Camb). 2012 May 16;48(39):4695-7. doi: 10.1039/c2cc30510k. Epub 2012 Apr 4.

Authors

Samuel Pearson¹, Wei Scarano, Martina H Stenzel

Affiliation

¹ Centre for Advanced Macromolecular Design, University of New South Wales, Sydney, Australia.

PMID: 22473015
DOI: 10.1039/c2cc30510k

Abstract

Polymeric versions of deacetylated auranofin, a gold complex with a sugar ligand, were prepared by post-modifying RAFT glycopolymers. Micellisation of a block copolymer containing pendant Au(I) units produced nanoparticles with an increased anti-proliferative effect against OVCAR-3 human ovarian carcinoma cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Auranofin / chemistry*
Auranofin / pharmacology
Cell Line, Tumor
Drug Delivery Systems*
Female
Gold / chemistry*
Humans
Magnetic Resonance Spectroscopy
Micelles*
Molecular Structure
Organometallic Compounds / chemical synthesis
Organometallic Compounds / chemistry
Ovarian Neoplasms / drug therapy

Substances

Antineoplastic Agents
Micelles
Organometallic Compounds
Auranofin
Gold