Abstract
We report the early prenatal ultrasound diagnosis of sirenomelia apus at 12+4 weeks in a patient with trimethoprim exposure in the vulnerable period. First-trimester scan revealed a malformed fetus with one femur, one small tibia, no feet, intraabdominal unilocular cystic structure, and two-vessel umbilical cord with allantoic cyst. Ultrasound visualization with two/three/four-dimensions was helpful in the process of parental counseling.
Copyright © 2012 Wiley Periodicals, Inc.
MeSH terms
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Abortion, Eugenic
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Adult
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Anti-Infective Agents, Urinary / adverse effects
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Ectromelia / chemically induced*
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Ectromelia / diagnostic imaging*
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Female
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Fetal Diseases / chemically induced*
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Fetal Diseases / diagnostic imaging*
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Humans
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Imaging, Three-Dimensional / methods
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Lower Extremity Deformities, Congenital / chemically induced*
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Lower Extremity Deformities, Congenital / diagnostic imaging*
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Pregnancy
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Pregnancy Trimester, First
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Prenatal Exposure Delayed Effects / diagnostic imaging*
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Trimethoprim / adverse effects*
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Ultrasonography, Prenatal / methods*
Substances
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Anti-Infective Agents, Urinary
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Trimethoprim