Neuroprotective effect of GK-2, a dipeptide mimetic of nerve growth factor, during experimental focal ischemia in middle cerebral artery basin

S B Seredenin; D N Silachev; T A Gudasheva; Yu A Pirogov; N K Isaev

doi:10.1007/s10517-011-1388-7

Neuroprotective effect of GK-2, a dipeptide mimetic of nerve growth factor, during experimental focal ischemia in middle cerebral artery basin

Bull Exp Biol Med. 2011 Sep;151(5):584-7. doi: 10.1007/s10517-011-1388-7.

Authors

S B Seredenin¹, D N Silachev, T A Gudasheva, Yu A Pirogov, N K Isaev

Affiliation

¹ V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.

PMID: 22462051
DOI: 10.1007/s10517-011-1388-7

Abstract

Magnetic resonance tomography, staining with triphenyltetrazolium chloride, and tests for evaluation of functional disturbances "cylinder" and "limb stimulation" showed that daily intraperitoneal injection of dipeptide mimetic of nerve growth factor GK-2 (1 mg/kg) for 6 days to rats with experimental focal ischemia provoked by unilateral intravascular occlusion of a branch of the middle cerebral artery significantly improved neurological deficit and decreased the infarction area.

MeSH terms

Amino Acid Motifs
Animals
Brain / drug effects
Brain / pathology
Brain Ischemia / drug therapy*
Dipeptides / pharmacology*
Dipeptides / therapeutic use
Disease Models, Animal
Infarction, Middle Cerebral Artery / drug therapy*
Male
Motor Activity / drug effects
Nerve Growth Factor / chemistry
Neuroprotective Agents / pharmacology*
Neuroprotective Agents / therapeutic use
Rats

Substances

Dipeptides
Neuroprotective Agents
bis(N-succinyl-glutamyllysin)hexamethylenediamine
Nerve Growth Factor