Abstract
Three recent studies have investigated interspecies retention of binding sites of peroxisome proliferator-activated receptor γ (PPARγ), the master regulator of adipocyte differention, between mouse and human adipocytes. Here we discuss the major findings and demonstrate that retention of binding events is highly context-dependent.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3-L1 Cells
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Adipocytes / metabolism*
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Animals
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Binding Sites
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CCAAT-Enhancer-Binding Proteins / metabolism
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Chromatin Immunoprecipitation*
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Histones / metabolism
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Humans
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Mice
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PPAR gamma / metabolism*
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Protein Binding
Substances
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CCAAT-Enhancer-Binding Proteins
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Histones
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PPAR gamma