Cross-species ChIP-seq studies provide insights into regulatory strategies of PPARγ in adipocytes

Transcription. 2012 Jan-Feb;3(1):19-24. doi: 10.4161/trns.3.1.19302.

Abstract

Three recent studies have investigated interspecies retention of binding sites of peroxisome proliferator-activated receptor γ (PPARγ), the master regulator of adipocyte differention, between mouse and human adipocytes. Here we discuss the major findings and demonstrate that retention of binding events is highly context-dependent.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3-L1 Cells
  • Adipocytes / metabolism*
  • Animals
  • Binding Sites
  • CCAAT-Enhancer-Binding Proteins / metabolism
  • Chromatin Immunoprecipitation*
  • Histones / metabolism
  • Humans
  • Mice
  • PPAR gamma / metabolism*
  • Protein Binding

Substances

  • CCAAT-Enhancer-Binding Proteins
  • Histones
  • PPAR gamma