Preparation of trifluoromethyl-substituted aziridines with in situ generated CF3CHN2

Stefan A Künzi; Bill Morandi; Erick M Carreira

doi:10.1021/ol300539e

Preparation of trifluoromethyl-substituted aziridines with in situ generated CF3CHN2

Org Lett. 2012 Apr 6;14(7):1900-1. doi: 10.1021/ol300539e. Epub 2012 Mar 28.

Authors

Stefan A Künzi¹, Bill Morandi, Erick M Carreira

Affiliation

¹ Laboratorium für Organische Chemie, ETH Zürich, CH-8093 Zürich, Switzerland.

PMID: 22455627
DOI: 10.1021/ol300539e

Abstract

Direct access to trifluoromethyl-substituted aziridines through the use of a protocol in which trifluoromethyl diazomethane is generated in situ and subsequently undergoes addition to activated imines is reported.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aziridines / chemical synthesis*
Aziridines / chemistry
Combinatorial Chemistry Techniques
Diazomethane / analogs & derivatives*
Diazomethane / chemistry*
Hydrocarbons, Fluorinated / chemical synthesis*
Hydrocarbons, Fluorinated / chemistry*
Imines / chemistry
Molecular Structure

Substances

Aziridines
Hydrocarbons, Fluorinated
Imines
Diazomethane