The biology of protein kinase C

Adv Exp Med Biol. 2012:740:639-61. doi: 10.1007/978-94-007-2888-2_28.

Abstract

This review gives a basic introduction to the biology of protein kinase C, one of the first calcium-dependent kinases to be discovered. We review the structure and function of protein kinase C, along with some of the substrates of individual isoforms. We then review strategies for inhibiting PKC in experimental systems and finally discuss the therapeutic potential of targeting PKC. Each aspect is covered in summary, with links to detailed resources where appropriate.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Hematologic Neoplasms / drug therapy
  • Humans
  • Insulin Resistance
  • Neurodegenerative Diseases / drug therapy
  • Phosphorylation
  • Protein Kinase C / antagonists & inhibitors
  • Protein Kinase C / chemistry
  • Protein Kinase C / physiology*
  • Substance-Related Disorders / drug therapy

Substances

  • Protein Kinase C