Correction of furosemide-induced magnesium deficiency with different stereoisomers of organic magnesium salts: a comparative study
Bull Exp Biol Med. 2011 Jul;151(3):333-5.
doi: 10.1007/s10517-011-1323-y.
[Article in
English,
Russian]
Affiliation
- 1 Department of Pharmacology, Research Institute of Pharmacology, Volgograd State Medical University, Russia. farm@vlpost.ru
Abstract
We compared the efficiency of different stereoisomers of organic magnesium salts (Mg DL-, Mg D-, and Mg L-aspartate and Mg L- and Mg DL-glutamate) after oral administration under conditions of furosemide-induced magnesium deficiency. The time to complete compensation of erythrocyte magnesium level was 5 days for Mg L-aspartate, 10 and 8 days for Mg L-glutamate and Mg D-aspartate, respectively, and 11 days for Mg DL-aspartate and Mg DL-glutamate. These findings attest to better bioavailability of Mg complex with L-stereoisomer of aspartate in comparison with DL and D-stereoisomers and stereoisomers of Mg glutamate.
MeSH terms
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Animals
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Aspartic Acid / administration & dosage
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Aspartic Acid / pharmacology
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Furosemide / toxicity*
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Magnesium / administration & dosage
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Magnesium / pharmacology*
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Magnesium Compounds / administration & dosage
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Magnesium Compounds / pharmacology*
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Magnesium Deficiency / chemically induced
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Magnesium Deficiency / drug therapy*
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Male
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Rats
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Stereoisomerism
Substances
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Magnesium Compounds
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Aspartic Acid
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Furosemide
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Magnesium