Cytotoxic dimeric indole alkaloids from Catharanthus roseus

Fitoterapia. 2012 Jun;83(4):765-9. doi: 10.1016/j.fitote.2012.03.007. Epub 2012 Mar 13.

Abstract

Three new dimeric indole alkaloids (1-3), together with five known ones (4-8), were isolated from the whole plants of Catharanthus roseus. The structures and absolute configurations of new compounds were elucidated by means of NMR and CD analyses. All these compounds were evaluated for their in vitro cytotoxic activities against human breast cancer cell line MDA-MB-231.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Breast Neoplasms / drug therapy*
  • Catharanthus / chemistry*
  • Cell Line, Tumor
  • Female
  • Humans
  • Indole Alkaloids / isolation & purification
  • Indole Alkaloids / pharmacology
  • Indole Alkaloids / therapeutic use*
  • Molecular Structure
  • Phytotherapy*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*

Substances

  • 14',15'-didehydrocyclovinblastine
  • 17-deacetoxycyclovinblastine
  • 17-deacetoxyvinamidine
  • Antineoplastic Agents, Phytogenic
  • Indole Alkaloids
  • Plant Extracts