Optimized angle scanning method for array sample detection in surface plasmon resonance biosensor

Appl Opt. 2012 Mar 20;51(9):1245-50. doi: 10.1364/AO.51.001245.

Abstract

An optimized angle scanning method is presented for array sample detection in a surface plasmon resonance biosensor. It provides a way to find the optimal rotation axis in the prism to resolve the drifting problem of the light incidence point on samples in the plane prism-coupling mode. The detection of array samples can be achieved by the translation of the prism along a particular direction. The validity of this method is theoretically analyzed and demonstrated by experiments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Equipment Design
  • Microarray Analysis / methods*
  • Surface Plasmon Resonance / methods*